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Chromatography Categories
1. Water Corporation
Prep SFC System
HPLC Systems
2. Buchi, Switzerland
Supercritical Fluid Chromatography System
PREPARATIVE SFC
3. Knauer GMBH, Germany
4.Hitachi High-Technologies Corporation
Waters Corporation
Economy Inexus Brand UV Visible Double Beam
Spectrophotometer
Model: Prep SFC 150 Mgm System
A greener approach to high throughput purification
Designed for high throughput, semi-prep to preparative scale purifications, the Prep SFC 150 Mgm™ System is made for repeat injection (bulk purification) of Chiral and Achiral compounds.
- The SFC 150 Mgm system has a maximum flow rate, CO2 and co-solvent combined, up to 150mL/minute allowing use of 19mm and 30mm columns. It also has capacity for 6 fraction collection positions (2 Liter each).
- Controlled by the Waters Software running under Windows 10, the user can take advantage of a new intuitive graphical interface. The Prep SFC 150 Mgm System operates at flow rates higher than traditional HPLC systems without significant increases in back pressure, allowing for high-speed SFC purification and improved resolution of compounds, leading to higher purity isolations.
- The Waters Prep SFC 150 Mgm System is perfectly suited for laboratories seeking to adopt a greener approach to high throughput purification. The Prep SFC 150 Mgm System is the ideal choice when reduction of normal-phase solvent usage and disposal is a critically important step for purification laboratories wanting to become more environmentally friendly.
- SFC systems utilize liquid Carbon Dioxide (CO2) as its main mobile phase in combination with one or more organic solvents resulting in faster equilibration, lower pressure drops across the column, solvent reduction and lower cost per sample. The process is reproducible and applicable to a wide range of compounds relevant in the Pharmaceutical, Life Sciences, Chemical Materials and Food & Environmental markets.
Waters Corporation
Economy Inexus Brand UV Visible Double Beam
Spectrophotometer
Model: Prep 350 SFC System
Waters' suite of bulk-scale supercritical fluid chromatography (SFC) purification systems offers the optimal system for the amount of sample you need to purify. These systems easily allow you to purify a large amount of one sample. When faster and more cost-effective means sustainable business operations, SFC is the purification technique that makes the difference.
Preparative - scale SFC 350 systems are automated systems that features co-solvent gradient, high pressure separators for quantitative recovery of purified products, such as enantiomers, complex synthetic chemicals and natural products. They are designed for chiral and achiral separations.
- High pressure CO2 pump
- High pressure co-solvent pump
- Injection module
- UV-Vis detector
- Fraction collection module
- Automated Back Pressure Regulator (ABPR)
- ChromScope software
Waters Corporation
High Performance Liquid
Chromatography Systems:
Model: Arc HPLC
Highly reliable, low complexity, accurate routine analysis for all
Ever-evolving regulations are impacting liquid chromatography (LC) method approaches for product quality control and beyond. With the Waters Arc HPLC System, you can count on high-efficiency separations and quality data to meet your regulatory requirements with confidence.
With Arc HPLC System, you can easily replicate and improve the performance of your existing LC methods without compromising data quality eliminating the burdens of older, less efficient LC systems. Rugged and dependable, Arc HPLC System delivers the ideal balance of performance and value for right-the-first-time analysis..
- Enhance performance without redeveloping your method
- Run methods with greater robustness over traditional HPLCs
- Easily replicate and enhance existing HPLC methods with low analyte carryover, high injection precision, and high back pressure tolerance
- Seamlessly receive transferred methods from other HPLC platforms, preserving analyte retention time and reproducibility of your analysis
- Support compliance with Empower Chromatography Data System (CDS), the gold standard, compliant-ready software
Waters Corporation
High Performance Liquid
Chromatography Systems:
Model: Alliance HPLC
Defined by dependability - today, and in the future:
- Time-tested, flexible, and reliable workhorse for your HPLC separations
- Integrated solvent and sample management with consistent system-to-system performance and high reproducibility
- A history of continued system improvements ensures the hightest in HPLC performance
- Simplify your daily LC system start-up with advanced software functionality
- Excellence through the years
- Performance that exceeds your method requirements
- Advancements in LC chemistry and mass detection
Features and Benefits:
- Quaternary solvent blending supports isocratic and gradient applications
- Advanced solvent delivery capabilities
- Variable injection volumes from 0.1 to 100 uL
- Detection capabilities include photodiode array, UV/Vis, fluorescence.
- GMP, GLP, ISO 17025, USP 1058 – Compliance ready
- Flexibility of running multiple methods on demand
- Supported in Empower, MassLynx, and several 3rd party software packages.
Buchi- Supercritical Fluid Chromatography System
Parallel HPLC / SFC
- It is not necessary to spend time adapting methods to the new system or to purchase any new costly HPLC columns. The users can continue to use all the methods and separation material that they were using with their conventional HPLC systems.
- The Sepmatix 8x Screening system can separate substances on eight different separation columns simultaneously. This significantly increases sample throughput.
- The system consists of three modules: an 8x Flow Control low viscosity version with flow rates of between 0.25 to 1.25 ml/min; an autosampler with syringe pump which injects samples from standard microtiter plates or deep-well microtiter plates onto eight columns (also suitable for vial racks); and an 8x Diode Array Detector with eight analytical flow cells applicable for the spectral range of 200 to 600 nanometres.
- The required space for the Sepmatix system is only 55 x 55 x 90 centimetres (W x D X H).
- The Sepmatix 8x Flow Control is available as an analytical version (with flow rates from 0.25 to 1.5 m / min per channel), a semiprep version (1.5 to 6.0 ml / min per channel) and a prep version (6.0 to 20 ml / min per channel).
Buchi- Supercritical Fluid Chromatography System
Model: Sepmatix 8X Screening SFC
- The Sepmatix 8x Screening SFC system combines Sepiatec’s proven parallel HPLC technology with the advantages of supercritical fluid chromatography.
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Best peak resolution: The superb Screening Wizard Software clearly displays the separations achieved in up to 80 chromatograms at the same time. The separation with the best peak resolution is immediately discernible. The software considerably reduces the amount of time the user needs for the selection process. The overview display is extremely suitable for presentations.
As far as the Sepmatix 8x SFC systems technical features are concerned, only one CO2 pump and one modifier pump are needed. Using Sepiatec’s patented Flow Control the flow is divided into eight channels and regulated exactly by electronically controlled valves. -
High Standard Equipment: A back pressure regulator, an autosampler, an eight channel diode array detector and a column oven for heating and cooling purposes are part of the standard equipment.
With minor modifications the Sepmatix 8x SFC system is also suited to chromatography using organic solvents.
Buchi- Supercritical Fluid Chromatography System
PREPARATIVE SFC
Model: Prep SFC 50
- Preparative Scale Separation – Compact Design
- The Prep SFC 50 from Sepiatec is a compact and easy-to-use chromatography system for preparative separations on small columns by means of supercritical fluid chromatography (SFC).
- The system offers the comprehensive benefits of SFC technology, such as faster separations, lower costs due to reduced consumption of organic solvents, as well as being more environmentally friendly at increased safety.
- The Prep SFC 50 is equipped with two 400 bar high-pressure pumps with 30 ml pump heads. The total flow – at a modifier portion of 40 % – amounts to 50 ml/min. This way, chromatography columns with inner diameters ranging from 4 to 16 mm, and a length of 250 mm can be used.
- The column oven, containing the chromatography columns together with the injection valve and the UV flow cell, is heatable up to 70° C so that a uniform temperature is ensured. The Prep SFC 50 system is available with 8 gas-liquid-separators.
- As fractions are collected in unpressurized state, not only safety is increased, but also handling is simplified, and limitations with respect to the size of fraction volumes do not exist. This option proves to be extremely convenient when working with stack injections.
- As the dimensions of the Prep SFC 50 together with the integrated system controller and 15.6” touch screen amount to only 56 x 60 x 88 cm (W x D x H) this system requires a minimum of space in the laboratory. A separate computer or monitor is not necessary.
- As the dimensions of the Prep SFC 50 together with the integrated system controller and 15.6” touch screen amount to only 56 x 60 x 88 cm (W x D x H) this system requires a minimum of space in the laboratory. A separate computer or monitor is not necessary.
- The equipment of the Prep SFC 50 system includes:
- High pressure pump for CO2.
- High pressure pump for modifiers.
- Adjustable back pressure regulator.
- Syringe pump for sample injection.
- UV detector.
- Integrated system controller.
- 15.6“ touch screen.
- Prep SFC control software.
- Additional computer at a separate work site can also be connected.
Buchi- Supercritical Fluid Chromatography System
PREPARATIVE SFC
Model: Prep SFC 250
- Preparative Scale Separation – Compact Design
- Sepiatec’s new Prep SFC 250 system is a compact benchtop unit designed for preparative separation using supercritical fluid chromatography. Measuring just 72 x 60 x 88 cm (W x D x H) the system offers all advantages of SFC technology such as fast separation, reduced consumption of organic solvents, lower costs, improved environmental compatibility and increased safety.
- The Prep SFC 250 system uses two high-pressure pumps fitted with 150 ml pump heads. Total flow rates of up to 250 ml of supercritical fluid per minute can be achieved at a modifier portion of 40%. This allows the operator to use separation columns with internal diameters of 15 to 30 mm and lengths of 250 mm.
- Due to its compact design, the footprint of the Prep SFC 250 system is comparatively small and precious laboratory space can be saved. The clearly arranged assembly of the Prep SFC 250 system allows easy access to all of its modules. The fractionation module includes a selector valve and 9 gas-liquid separators (1 for waste). It is designed for 8 fraction bottles with a volume of 1 litre each. Due to the flexible outlets even bigger sample containers with volumes up to several litres can be used.
- A system controller with current performance characteristics is built into the device. There is no need for a separate computer or monitor, and no additional bench space is required.
- The very user-friendly Prep SFC control software runs the entire device and contains functions such as stack injection, peak detection and on-the-fly editing. Data is entered via the 15.6‘‘ touch screen, which is placed ergonomically on the upper front of the Prep SFC 250 system.
- The equipment of the Prep SFC 250 system includes:
- High pressure pump for CO2
- High pressure pump for modifiers
- Adjustable back pressure regulator
- Syringe pump for sample injection.
- UV detector.
- Integrated system controller.
- 15.6“ touch screen.
- Prep SFC control software.
- Additional computer at a separate work site can also be connected.
Buchi- Supercritical Fluid Chromatography System
PREPARATIVE SFC
Model: Prep SFC 660
- The Efficient Solution for Preparative Separations
- The Prep SFC 660 system, developed by Sepiatec, represents a powerful solution for preparative separations by means of supercritical fluid chromatography (SFC). The unit has been designed for flow rates of up to 660 ml/min at a modifier portion of 40 %.
- In spite of its remarkable capacity, the Prep SFC 660 system features a compact design with measurements of 150 x 68 x 178 cm (W x D x H), so that integration within a walk-in laboratory hood does not create any problem. Additionally, below the unit, several large fraction vessels or a safety cabinet for solvents may be placed.
- The Prep SFC 660 is equipped with three 400 bar high-pressure pumps. A CO2 pump with 400 ml pump head, a modifier pump with 250 ml pump head and a modifier/add-on pump with 150 ml pump head. The total flow – at a modifier portion of 40 % – amounts to 660 ml/min. Up to three different organic modifiers can be mixed and used for separations.
- Besides the column mounting, the injection valve and the UV flow cell are also integrated within the column oven, which is heatable up to 50° Celsius. Separation columns with inner diameters between 25 and 50 mm and a length of up to 800 mm are admissible.
- When working in “Single Mode”, up to 8 fractions can be collected (CO2 flow 180 ml/min)."
- As fractions are collected in unpressurized state, not only safety is increased, but also handling is simplified, and limitations with respect to the size of fraction volumes do not exist. This option proves to be extremely convenient when working with stack injections."
- The equipment of the Prep SFC 660 system includes:
- 400 ml high pressure pump for CO2
- 250 ml high pressure pump for organic modifiers
- 150 ml high pressure pump for organic modifiers
- Gradient module for the mixing of modifiers.
- Heatable column oven.
- Backpressure regulator
- UV detector
- 8 gas-liquid-separators for fractions.
- Powerful cooling module
- Integrated system controller with 15.6” touch-screen
- USB connectors, Ethernet, and HDMI connector
- Prep SFC control software
Buchi- Supercritical Fluid Chromatography System
PREPARATIVE SFC
Model: Prep SFC M 5
- Versatile SFC System for Chiral and Achiral Separations
- Sepiatec’s Prep SFC M5 system is a preparative system for separating chiral and achiral samples using supercritical fluid chromatography.
- The Prep SFC M5 system consists of the main module and the collector module. Both modules form a functional unit that can be configured in a variety of ways with different equipment.
- The main module can be equipped with up to three high pressure pumps, a CO2 pump, a modifier pump and an optional add-on pump for separations with low modifier portions. The available options include CO2 and modifier pumps with 30 ml pump heads, 400 bar (Prep SFC M5-50) or CO2 and modifier pumps with 150 ml pump heads, 400 bar (Prep SFC M5-250).
- The integrated auto sampler can accommodate two standard or two deep well microtiter plates with 24 wells and a volume of 10 ml each or racks with up to 60 sample vials with a volume of 1.5 ml each.
- The heatable column oven contains up to 10 separation columns with internal diameter of 4 to 30 mm and a length of 250 mm.
- Standard equipment in the main module is a UV detector for measuring in the range of 190 – 500 nm. Other detectors, such as a DAD or an ELSD, can also be connected.
- An integrated system controller and a 15.6” TFT touch screen are used to input all data for sample separations. No additional computer is needed, reducing the space required for the Prep SFC M5 system to a width of just 92 cm.
- The post heater and the back pressure regulator are integrated within the collector module. The continuously operating gas-liquid separator is located at the front of the collector module; it removes residual CO2 from the isolated compounds.
- The Prep SFC M5 system can be fitted with a carousel fraction collector which can accommodate collection vessels with volumes ranging from 10 to 500 ml.
- Alternatively, an XY-fraction collector for vials with volumes of 10 or 60 ml is available. A total of up to 195 fractions can be collected.
Knauer, Germany
Azura Preparative HPLC
Model: Alliance HPLC
- Upscale systems — Compact, Lab, and Pilot
- Pumps: Pressure (50 bar to 400 bar), Isocratic (50 mL/min), Isocratic/HPG (50 mL/min), Isocratic/HPG/LPG (1000 mL/min)
- Flexible solvent selection: 80 mL/min and 1 000 mL/min
- Docking station for pumps, valves, and detectors
- Automated eluent selection — up to 12 different eluents
- Column switching feature for screening and scale up
- Stacked injection function to increase efficiency and save eluent
- Detector choices: Mufti-channel UV-VIS, Diode array, Light scattering, Conductivity monitor
- Versatile fraction collection: manual, time-based, peak-based, threshold function
- Flexible instrument control: PurityChrom@, ChromeIeonTM, OpenLab@ EZCrhom, ClarityChrom@
- Advanced purification and improved resolution by recycling mode
Knauer, Germany
Azura Bio-Purification FPLC
Azura Bio-Purification FPLC
- Lab to pilot scale
- Biocompatible / metal-free FPLC
- Methods: Size Exclusion Chromatography, Affinity Chromatography, Ion -Exchange Chromatography, Hydrophobic Interaction Chromatography.
- Pumps: Isocratic (10 or 50 mL/min)e Gradient (10 or 50 mL/min), Scale-up (Binary up to 800 mL/min, Ternary up to 220 mL/min)
- Buffer selection, automated switching, 2×2 selection valve for binary, 4 x selection for ternary, configure up to 8 buffers with additional valves.
- Detector choices: UV-VIS, Diode array, Refractive index, Fluorescence, Conductivity, PH, Light scattering, Analog integration for further detectors.
- Fractionation valve: for 6 to 16 fractions, flowrates up to 1000 ml_/min.
- Fraction collector: from 96-well microplates up to bottles or funnels, up to 1000 mL/min.
- Autosampler: Up to 10 mL injection volume, from microtiter plates to IO mL vials
- Software: PurityChromg, highly flexible method writing, intuitive user-interface, volume or time-based, with special features like system visualisation, hold & adjust option, extended threshold functions, check for impurities.
- Sepapure@ FPLC columns based on Agarose and Dextran
Knauer, Germany
Azura SMB Systems
Azura SMB Systems
- Continuous separation and extraction of binary mixtures in two fractions
- Work with ease for chiral separations or mixtures with trailing (key product) peak
- Separate binary mixtures in gram—scale (Lab) and/or kilogram—scale (Pilot)
- Save cost — up to 90% for solvent and 80% for solid phase
- High-performance pumps to extract, raffinate, and eluent
- Freely configurable according to special needs such as closed-loop and open-loop
- PurityChrom@ MCC software to control and monitor multi-column systems
- Bio-compatible systems
- Fractionation valve: for 6 to 16 fractions, flowrates up to 1000 ml_/min.
- Fraction collector: from 96-well microplates up to bottles or funnels, up to 1000 mL/min.
- Autosampler: Up to 10 mL injection volume, from microtiter plates to IO mL vials
- Software: PurityChromg, highly flexible method writing, intuitive user-interface, volume or time-based, with special features like system visualisation, hold & adjust option, extended threshold functions, check for impurities.
- Sepapure@ FPLC columns based on Agarose and Dextran
Knauer, Germany
IJM NoneScaler
IJM None Scaler
KNAUER's benchtop IJM NanoScaler system is designed for lipid nanoparticle R&D - allowing scientists to screen for the optimal process parameters for the formulation of API-containing lipid nanoparticles.
Knauer, Germany
IJM NoneScaler pro
IJM NoneScaler pro
KNAUER's innovative IJM Nano scaler Pro system is designed for automated lab-scale formulation of liquid nanoparticles - allowing scientists to screen early-stage API candidates with different lipid compositions
Hitachi High-Technologies Corporation
High Speed Amino Acid Analyzer (AAA)
Model: LA8080
- Highly reliable post-column derivatization
- Ultra fast analysis - 30 minutes
- Minimal foot print saves laboratory space
- Longer shelf life of the reagent with online mixing
- Revolutionary and patented TDE3 reactor to improve heat transfer efficiency
- Standard and performic acid oxidation method for protein hydrolyzate (PH method)
- Method for analysis for physiological fludis (PF method)
- Method validated for European Pharmacopeia & USFDA
- Single sample analysis & sequence analysis
- Excellent reproductiblity of peak retention time & peak area
- Detection limit of 2.5 pico-moles
- Pump with a flow rate between 0.001 mL/min & 1 mL/min