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Carbon Dioxide is a versatile solvent for wide-range of applications. It is chemically pure, stable and non-polar solvent that can be manipulated by changing pressure and temperature conditions to achieve subcritical or supercritical state. Carbon Dioxide is easily removed post-processing offering significant advantage when working with thermally labile compounds or where residual solvents are not desirable. Carbon Dioxide is widely available and is typically a byproduct of other industrial processes and can be recycled after supercritical processing.

Processing with carbon dioxide requires keen understanding of this medium and the challenges posed as compared to traditional solvents. Carbon Dioxide density can vary based on the process conditions giving the user versatility in terms of solvating power and is an advantage over traditional solvents. This range of solvating power also poses unique challenges in system design and manufacturing. Selection of materials of construction in contact with solvents in presence of carbon dioxide is critical for success especially where range of experimental conditions will be employed. Most material compatibility charts indicate compatibility with pure fluids. However, there are combination of solvents present with carbon dioxide under wide range of conditions making construction material selection challenging. Practical experience is critical and this is where D2P’s experience is an advantage. Design 2 Product’s systems incorporates over 20 years of supercritical fluids experience in designing, manufacturing and delivering solutions for hundreds of processes.

Faster and cleaner technology to keep your product safe, uncontaminated, and natural.

Design2Product Inc, Supercritical Fluid Extraction (SFE) systems extract chemical compounds
using supercritical fluid instead of an organic solvent. The result is an extract with
little or no residual solvent, superior purity and yield, and lower operating costs compared to solvent-based systems.

It’s no wonder that industries from natural products, food and flavors,
pharmaceuticals, to nutraceuticals, polymers, chemicals, and cleaning are turning
to Waters’ high quality suite of SFE solutions.

Supercritical Fluid Extraction (SFE) Systems

Design2Product Inc, Supercritical Fluid Extraction (SFE) Systems extract chemical compounds using supercritical carbon dioxide instead of an organic solvent. The supercritical fluid state occurs when a fluid is above its critical temperature (Tc) and critical pressure (Pc), when it is between the typical gas and liquid state. Manipulating the temperature and pressure of the fluid can solubilize the material of interest and selectively extract it. The sample is placed in an extraction vessel and pressurized with CO2 to dissolve the sample. Transferred to a fraction collector, the contents are depressurized and the CO2 loses its solvating power causing the desired material to precipitate. The condensed CO2 can be recycled.



SFE applications in the food, pharmaceutical, and fine chemical industries:

  • Decaffeinating of coffee and tea
  • Extraction of essential oils (vegetable and fish oils)
  • Extraction of flavors from natural resources (nutraceuticals)
  • Extraction of ingredients from spices and red peppers
  • Extraction of fat from food products
  • Fractionation of polymeric materials
  • Extraction from natural products
  • Photo–resist cleaning